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19 January 2007 @ 09:46 am
Argh!!! PIRATES!!! HHV-8: Herpesviruses and you.  

Came upon this in my reading. First, as always, who can read this stuff! Second, PIRATES!

"In addition, HHV-8 has a number of genes such as ORF K12 (encodes the highly expressed transcript, kaposin), and ORF K1, a transmembrane protein that interacts with immunoreceptor kinases, which are likely to play a role in tumorigenesis. Functional studies suggest that these pirated genes may help the virus to evade immune responses, prevent cell cycle shutdown and interrupt activation of apoptotic pathways. This strategy has been referred to as "molecular piracy" of host cell genes. Like many complex DNA viruses, HHV-8 encodes a number of immunomodulatory factors:

Jack Black Fas signalling in (virus-infected) target cells is triggered by Fas receptor multimerization on binding with membrane-bound Fas-L. Subsequent recruitment of the adaptor molecule Fas-activated death domain (FADD) leads to upstream caspase (caspase 8) autoactivation and release, leading to downstream effector capsase activation (caspase-3, -6, -7) & apoptosis. Death-receptor triggered apoptosis can be inhibited at several points: at the initiator stage by FLIP or in the amplification loop by bcl-2. HHV-8 v-FLIP block apoptosis in virus-infected cells. In addition, the vius also encodes a decoy (non-signalling) Fas receptor.
(Rezaee SA, et al. Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. J Gen Virol. 2006 87: 1781)

Plus, Pirates just kind of... GO with oncology